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Breast Anatomy ] [ Staging ]

Breast Cancer Staging

Getting the best resources activated are essential.  Breast cancer isn't an overnight killer.  Take time to get the best information and resources.  I highly recommend you order the Moss Report for your particular situation.  Read more about that here

Every diagnosis of breast cancer eventually leads to a discussion on the stage of the cancer.  Staging yields “ballpark” prognostic indicators, and is essential in determining therapeutic choices.  Without appearing too jaded, it appears that therapeutic choices are rendered in a cookbook fashion.  This is not to say that this approach is without significant merit.  Accumulated research has demonstrated which combinations of surgery, chemotherapy and radiation have the greatest statistical chance of success. 

The American Joint Committee on Cancer (AJCC) staging system provides a strategy for grouping patients with respect to prognosis.  The primary determinant of therapeutic decisions is the status of pertinent lymph nodes, estrogen and progesterone receptor levels in the tumor tissue, menopausal status and overall health. 

The staging method of the AJCC utilizes stage information from three parameters: Stage of the actual tumor, lymph node involvement, and degree of metastasis.  The term TNM is used as an abbreviation. 

Tumor Stage:

TX:      Primary tumor cannot be assessed.

TO:      No evidence of primary tumor

Tis:            Carcinoma in situ (i.e. contained such as intraductal carcinoma, lobular carcinoma in situ etc.)

T1:       Tumor 2.0 cm in greatest dimension

T1a:     Tumor more than 0.1 but less than 0.5 cm in greatest dimension

T1b:     Tumor more than 0.5cm but less than 1.0cm

T1c:     Tumor more than 1.0 but less than 2.0 cm

T2:       Tumor more than 2.0 but less than 5.0 cm

T3:       Tumor more than 5.0 cm

T4:       Tumor of any size which invades skin or chest wall (excluding pectoral muscles)

T4a:            Extension into chest wall

T4b:     Edema or ulceration of the skin of the breast

T4c:     Both T4a and T4b

T4d:            Inflammatory carcinoma

 

Lymph Node Involvement:

NX:      Cannot be assessed

N0:      No regional lymph node involvement

N1:            Metastasis to movable ipsilateral axillary lymph nodes

N2:            Metastasis to ipsilateral axillary lymph nodes fixed to each other or other structures.

N3:            Metastasis to ipsilateral internal mammary lymph nodes.

 

Metastasis:

MX:     Cannot be assessed

M0:      No distant metastasis

M1:      Distant Metastasis including lymph nodes. 

 

 All of the above are then organized into stage groupings.  Stage groupings are what most patients are familiar with.  They are as follows

Stage 0: 

Tis, N0, M0

Stage 1:

T1, N0, M0

Stage 2A                       

T0, N1, M0  T1, N1, M0  T2, N0, M0

Stage 2B:

                       

T2, N1, M0 T3, N0, M0

Stage 3A:                                   

T0, N2, M0 T1, N2, M0  T2, N2, M0  T3, N1, M0

T3, N2, M0

Stage 3B:       

T 4, Any N, M0 Any T, N3, M0

Stage 4:

Any T, Any N, M1

This information probably appears technical and irrelevant to many, but for those with a diagnosis of breast cancer it is the language of prognosis and treatment protocols.     

Article by Michael Guthrie, R.Ph.

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"Alternative Cancer Treatments"  Michael Guthrie, R.Ph.  CGP 2003-2006
Updated May 7, 2006